Contract Research Partnership: Eve Technologies and the CNBE

A strategic partnership agreement in biomarker discovery was signed by Eve Technologies and Centre national de biologie expérimentale (CNBE) of Institut national de recherche scientifique (INRS).

Who is the CNBE?

The CNBE operates as a contract research organization as an animal research facility.  They offer research services such as drug development and preclinical animal studies.

  • Turnkey contract research (CRO services)
  • Specialized in exploratory non-GLP studies:
    • Toxicity/safety
    • Drug Metabolism & Pharmacokinetic
    • Drug efficacy study
  • 78 multi-functional animal housing rooms
  • Fast turnaround time & flexibility
  • Highly qualified personnel
  • Animal husbandry available for your own studies
  • 22 years experience

What does this partnership mean for our research clients?

This unique alliance provides integrated contractual services for both animal studies in various species and biomarker identification.  Thanks to this agreement, clients will be able to utilize the expertise of each organization to strengthen their drug development pipeline.

Services Provided

Species for Animal Research

Non-human primates Rodents Large Animals Dogs Unusual species Others
Cynomolgus macaques (colony) Mice (including transgenic, nude, SCID) Pigs Beagle dogs (colony) Ferrets Rabbits
Rhesus macaques Rats (including transgenic, nude, SCID) Minipigs Mongrel dogs Cotton rats Chicken
Capuchin monkeys Guinea pigs Goats Chicks
Squirrel monkeys Hamsters Sheep Turkeys

 

Drug Metabolism & Pharmacokinetic Studies (DMPK)

MULTIPLE ROUTES OF ADMINISTRATION

• per os (gavage)
• intravenous (IV)
• intraperitoneal (IP)
• subcutaneous (SC)
• intramuscular (IM)
• intradermal (ID)
• intratechal (IT)
• endotracheal (ET)
• intravesical (Ive)

MULTIPLE ANIMAL SPECIES

• Permanent colony of 6 non-human primates (cynomolgus macaques)
• Permanent colony of 8 beagle dogs
• Rodents (mice and rats)
• Guinea pigs, ferrets, rabbits
• Farm animals (swine, goat, sheep, poultry)

SAMPLING

• Blood, serum, plasma
• Urine and feces
• Organs
• Bone marrow

SPECIALIZED PHARMACOKINETIC SERVICES

• Capillary microsampling available for mice (10-30 μL) >>> one mouse = one PK
• Cerebrospinal liquid (CSF) collection from rats and monkeys
• PK in knockout rats for drug transporters and xenobiotic sensors (e.g. MDR1, OCT1, PXR)
• PK in mice with human cancer (xenografted animals)
• PK in hyperlipidemic rats
(to reflect unhealthy total cholesterol level; present in 57% of Canadian of 40-59 years old)

FAST TURNAROUND AND FLEXIBILITY

• Days or weeks (not months)

 

Toxicity Studies

TOXICITY

• Dose-range finding study (MTD, NOAEL, NOEL)
• Lethal dose, 50% (LD50)
• Acute toxicity
• Chronic toxicity
• 7-day repeated administration toxicity
• Immunotoxicity & immunogenicity
• ECG & respiratory rate in non-human primates
• Skin reaction/Draize scoring
• Dermatology/biopsies
• Stem cell safety (Fox Chase SCID Beige model) and NHP
• Blood chemistry
• Hematology and coagulation

 

Drug Efficacy in Animal Models

VACCINE AND INFECTIOUS DISEASES

• BSL-2 (for both small and large animals)
• Bacterial and viral infectious models
• Murine endotoxemia models

ONCOLOGY

• Syngeneic, xenografted and PDX models
• in partnership with Woodland Biosciences Inc. (USA)

LIVER DISEASE

• Acute liver injury (D-GaIN and LPS-induced)
• NASH model (Nonalcoholic steatohepatitis)

IMMUNITY AND INFLAMMATION

• Wound healing
• Ischemic ear rabbit model
• Autoimmune disease
• Polyclonal antibody production (rabbit, sheep, goat)

CISPLATIN-INDUCED ACUTE AND DELAYED EMESIS MODELS (FERRETS)

• To test new anti-emetic drugs
• To evaluate possible emetic properties of a compound developed for other purposes

Where is the CNBE Located?

Contact the CNBE

Download the 2017 CNBE Animal Studies and Services Booklet

Eve Tech's Partners