Description
Unlock comprehensive insights into the complement system with our Complement Profile 13-Plex Panel. This assay provides detailed measurements of key complement proteins, including C1q, C3, C5a, and Mannose-Binding Lectin, essential for understanding the activation and regulation of the complement pathway.
Indications:
Use this test to identify relevant therapy targets, determine disease mechanisms, and diagnose or monitor the following conditions associated with complement system activation, regulation, and dysfunction:
- Autoimmune Diseases: Assess autoimmune conditions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis, where abnormal levels of complement components like C1q, C3, C4, and Mannose-Binding Lectin (MBL) can indicate complement activation and immune complex formation.
- Infectious Diseases: Evaluate the immune response in bacterial, viral, and fungal infections. Elevated levels of complement activation products like C3a, C5a, and Factor B can indicate an active immune response to infection.
- Complement Deficiencies: Support assessments of congenital deficiencies in complement components such as C2, C3, C4, and Factor H, which can predispose individuals to recurrent infections and autoimmune diseases.
- Kidney Diseases: Monitor complement-mediated kidney diseases such as membranoproliferative glomerulonephritis (MPGN) and atypical hemolytic uremic syndrome (aHUS), where complement components like C3, C3b/iC3b, Factor H, and Factor I are involved in disease pathogenesis.
- Inflammatory Conditions: Assess chronic inflammatory conditions such as inflammatory bowel disease (IBD) and vasculitis, where elevated levels of complement activation products like C5a and Factor D can indicate ongoing inflammation and tissue damage.
- Sepsis and Critical Illness: Diagnose and monitor sepsis and systemic inflammatory response syndrome (SIRS), where increased levels of complement activation fragments such as C3a, C5a, and sC5b-9 are markers of systemic inflammation and immune activation.
The complement cascade is activated in coagulation which makes serum an unacceptable sample type for this assay. The Complement Profile 13-Plex Panel is recommended for plasma only, EDTA preferred.
Explore the depth of immune response and inflammation with our detailed complement profiling.
Key Features:
- Comprehensive Biomarker Coverage: Provides a detailed analysis of 13 key complement proteins, ensuring a thorough diagnostic approach.
- CLIA Certified for Clinical Use: As a CLIA certified laboratory (High Complexity International Laboratory by the Centers for Medicare & Medicaid Services (CMS) CLIA# 99D2283230), we provide a panel that meets the highest standards of accuracy and reliability for clinical diagnostics.Â
- Versatility: Use this test for acute phase inflammatory detection.
- Reference intervals: Are available for PLASMA-EDTA.
- Affordable Assay Services: We offer some of the most affordable assay services available, making advanced diagnostics accessible for clinical applications.
- Swift Turnaround Time: We pride ourselves on a rapid turnaround time, with results typically delivered within 5 business days of receiving your specimen and payment.
Regulated Tests: Ensuring Quality and Accuracy
The LDT (Lab Developed Test) designation highlights that our tests are regulated by the Centers for Medicare & Medicaid Services (CMS) under CLIA, ensuring they meet stringent quality and accuracy standards. Unlike commercially distributed tests, which undergo FDA approval, our LDTs are developed and validated within our laboratory to provide specialized and reliable diagnostic insights tailored to your needs. This distinction underscores our commitment to maintaining the highest standards in testing and personalized care.
Eve Technologies is certified by the Centers for Medicare & Medicaid Services (CMS) as a High Complexity International Laboratory under the Clinical Laboratory Improvement Amendments (CLIA), specializing in Diagnostic Immunology with a subspecialty in General Immunology (CLIA# 99D2283230). Additionally, we hold a clinical and public health laboratory license with the California Department of Public Health (COS-90013367). Our certification underscores our commitment to rigorous standards.
Clinicians: Please check with your State Agency to determine if additional licensure or registration requirements may apply.
! The interpretation of these test results should be correlated with clinical findings and other diagnostic tests. Biomarker levels can vary due to many biological, physiological, and diurnal factors; their clinical significance must be assessed by a qualified healthcare professional. This information is not intended to be used as the sole basis for diagnosis or treatment decisions. ​