Active Caspase 9

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Description

Caspase-9 is an initiator caspase,[3] encoded by the CASP9 gene. CASP9 orthologs [4] have been identified in all mammals for which complete genome data are available. Unique orthologs are also present in lizards, lissamphibians, and teleosts.

The aspartic acid specific protease caspase-9 has been linked to the mitochondrial death pathway. It is activated during programmed cell death (apoptosis). Induction of stress signaling pathways JNK/SAPK causes release of cytochrome c from mitochondria and activation of apaf-1 (apoptosome), which in turn cleaves the pro-enzyme of caspase-9 into the active form.

Once initiated caspase-9 goes on to cleave procaspase-3& procaspase-7, which cleave several cellular targets, including poly ADP ribose polymerase.

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