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Human MSD® Discovery Assay® T1D Autoantibody 4-Plex Array (MSDT1DA4)

/ Human MSD® Discovery Assay® T1D Autoantibody 4-Plex Array (MSDT1DA4)
Ultrasensitive assay that simultaneously measures 4 key autoantibodies associated with Type 1 Diabetes (T1D) and pancreatic islet autoimmunity.
Autoantibodies to insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A)

Price
$88.97/sample (single analysis)

Sample Volume Requirements
Single analysis 50 μL
Duplicate analysis 75 μL

TO ORDER THIS ASSAY - DESIGN YOUR RESEARCH PROJECT BELOW

Species Type
Sample Type & Qty
Sample Tube Type
Pilot Analysis
Infectious Nature
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Species Type

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Sample Type & Qty

BAL Fluid

Number of Samples

Volume (uL)

Dilution Factor
This refers to the dilution factor of the samples that you are sending.

Cell Lysate

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CSF

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Plasma-Citrate

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Plasma-EDTA

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Plasma-Heparin

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Serum

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Synovial Fluid

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Volume (uL)

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This refers to the dilution factor of the samples that you are sending.

Tissue Homogenate

Number of Samples

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Dilution Factor
This refers to the dilution factor of the samples that you are sending.

Tissue/Cell Culture Supernatant

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Volume (uL)

Dilution Factor
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Urine

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Other

Sample

Number of Samples

Volume (uL)

Dilution Factor
This refers to the dilution factor of the samples that you are sending. Note that some assays recommend a dilution factor for assay performance or to reduce the demand on precious sample volume. For example, a number of rat and mouse cytokine arrays recommend a 2-fold dilution for serum/plasma samples (1 part sample and 1 part diluent) - please contact us for more information if needed.

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Sample Tube Type
Conforming tubes are 0.5-0.65mL snap cap tubes. Having a conforming tube helps us complete your analysis efficiently and accurately. A $4.00 charge per sample tube may be added to your order if sample tubes are non-conforming.

0.5-0.65ml Snap Cap

Other Tube Type (Fee applies)

Label Type
Conforming tube labeling is with a constant letter from your last name followed by consecutive numbers. (ie. Last name Smith: S1, S2, S3, etc.). Labelling tubes in this manner helps us complete your analysis efficiently and accurately. A $4.00 charge per sample tube may be added to your order if sample labelling is non-conforming.

1 letter and consecutive numbers (multiple letters and missing numbers are non-conforming)

Other Label Type (Attach sample list at checkout, fee applies)

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Pilot Analysis

Pilot runs are recommended for medium to large cohorts of samples that lack homogeneity (i.e. n>20 of tissue homogenate samples, cell culture samples, or less common sample types which can have higher sources of variability and/or unpredictable analyte levels). Running a pilot in such instances will ensure an optimal dilution factor is used before running your entire sample cohort. Pilot runs are ideally done on samples that reflect the expected experimental range and are provided as separate aliquots/separate samples designated for the pilot run.

None

Yes - I will include additional pilot samples (RECOMMENDED: to remove consideration for inter-assay variables between pilot and main sample cohort assay sessions.) We typically recommend 2, one sample with a low expected analyte concentration and one with a high, to encompass the range of the standard curve.

Yes – I will indicate pilot samples from within my cohort (CAUTION: pilot samples will not be run again with the main assay. Inter-assay variables may result in a batch effect. We typically recommend 2, one sample with a low expected analyte concentration and one with a high, to encompass the range of the standard curve.

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Infectious Nature
If your samples are of an infectious nature, please contact us PRIOR TO SHIPPING. Please DO NOT SHIP infectious samples unless you have contacted us for requirements.

No

Yes (please state the infectious nature for reivew prior to shipping)

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Review

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Description

Consider this assay for multiplex detection of four key autoantibodies associated with Type 1 Diabetes (T1D) and pancreatic islet autoimmunity.
The Human MSD® Discovery Assay® T1D Autoantibody 4-Plex Array (MSDT1DA4) measures autoantibodies to insulin (IAA), glutamic acid decarboxylase 65 (GADA), insulinoma-associated antigen-2 (IA-2A), and zinc transporter 8 (ZnT8A).
The four autoantibodies included in this panel are widely studied markers of T1D-associated humoral autoimmunity. Their combined measurement provides researchers with a convenient approach for investigating islet autoantibody profiles, the development and progression of autoimmunity, and changes in autoantibody responses over time.
Using MSD® electrochemiluminescence (ECL) technology and a bridging immunoassay format, all four autoantibodies are measured simultaneously in a single well. This multiplex approach reduces sample requirements and streamlines analysis compared with running individual autoantibody assays, making it particularly well suited to studies involving valuable samples, larger cohorts, or longitudinal sample collections.
The assay is designed for human serum and plasma. Although officially a human assay, MSD has advised that the panel has also been successfully evaluated by research groups using mouse samples. Mouse applications are considered exploratory and are not covered by the manufacturer’s performance specifications. Please contact us prior to ordering mouse or other non-standard sample types.
Optimized for Serum and Plasma samples. If you need to analyze other sample types, please contact us prior to ordering.
Research Use Only (RUO). Not for use in diagnostic procedures.